Institute for International Research

From Basic Principles to Practical Solutions

Strengthen your comprehension of molecular interactions.
Bring back new applications to incorporate immediately.
Advance your candidates ahead with fewer unknowns.

• Understanding molecular interactions and their applications in drug discovery & development
• Practical strategies for obtaining meaningful data on biomolecular interactions
• Linking in vitro affinity and kinetics to in vivo activity
• Alternative technologies for evaluating molecular interactions

• PK Assay strategies to support non-clinical and clinical studies
• Pharmacological and toxicological perspectives about which drug species should be measured
• Choosing a PK assay format: circulating target considerations
• Methods for measuring unbound therapeutic and “total” drug

• ADCs in preclinical and clinical development
• Unique challenges for ADC development
• Tools and current bioanalytical strategies
• Novel bioanalytical strategies

• Methods for in vitro assessment of Fc effector functionality
• Relate in vitro analyses to in vivo efficacy and toxicity
• Current state of Fc biology and Interaction of human IgG-Fc with FcyR
• Regulatory perspectives